Ionic storm in hypoxic/ischemic stress: Can opioid receptors subside it?
نویسندگان
چکیده
منابع مشابه
Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been...
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centuries, both in amedicinal and ‘recreational’ manner. Indeed, findings of fossilized opium poppy seeds dating as far back as 30 000 yr ago suggest the use of opium by Neanderthal man. In 1799, Friedrich Serturner discovered the major active ingredient of opium, which he named morphine and opioid pharmacology was born. Morphine and its derivates are used today for the treatment of acute and c...
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Unraveling the pathways and neurobiological mechanisms that underlie the regulation of physical and emotional stress responses in humans is of critical importance to understand vulnerability and resiliency factors to the development of a number of complex physical and psychopathological states. Dysregulation of central stress response circuits have been implicated in the establishment of condit...
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The amygdala is a forebrain region, which is known as a modulator of pain sensation. The amygdala, particularly the central nucleus, has high concentrations of enkephalins relative to dynorphins and has high concentrations of opioid receptors. We here studied the role of central nuclei of amygdala in morphine antinociception. Methods: In this study, we used 130 male Wistar rats (200- 250g). Bil...
متن کاملAdolescent storm and stress, reconsidered.
G. S. Hall's (1904) view that adolescence is a period of heightened "storm and stress" is reconsidered in light of contemporary research. The author provides a brief history of the storm-and-stress view and examines 3 key aspects of this view: conflict with parents, mood disruptions, and risk behavior. In all 3 areas, evidence supports a modified storm-and-stress view that takes into account in...
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ژورنال
عنوان ژورنال: Progress in Neurobiology
سال: 2010
ISSN: 0301-0082
DOI: 10.1016/j.pneurobio.2009.12.007